Pharmacy Technology

HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS

Contents ABSTRACT Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a...

COMPARATIVE PHARMACOGNOSTIC STUDIES OF THE LEAVES OF SOLANUM INCANUM LINN AND SOLANUM MELONGENA LINN (SOLANACEAE)

ABSTRACT Solanum incanum Linn. and Solanum melongena Linn (Solanaceae) are both shrubs or trees found in the sub-Saharan Africa and the Middle East. Both are...

DESIGN AND DEVELOPMENT OF A STARCH-BASED MULTIFUNCTIONAL EXCIPIENT FOR TABLET FORMULATION

ABSTRACT The concept of co-processing as a particle engineering technique has been used as a tool to improve the functionality of many existing excipients. This...

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RISPERIDONE IN PURE AND TABLET DOSAGE FORMS

Contents ABSTRACT Two simple, sensitive, accurate and extraction-free spectrophotometric methods were developed and described for the determination of risperidone in pure and in tablet dosage forms....

EFFECT OF CHRONOMODULATED ARTESUNATE ON RENAL AND HAEMATOLOGICAL TOXICITY IN CISPLATIN-TREATED WISTAR RATS

Contents ABSTRACT Cisplatin is a non-cell-cycle dependent chemotherapeutic agent used in the treatment of several common solid tumours. However, an array of serious toxicities in various...

EFFECT OF MICRONUTRIENT SUPPLEMENTATION ON SOME INDICES OF HIV INFECTION PROGRESSION AMONG ANTIRETROVIRAL NAÏVE PATIENTS ATTENDING HIV CLINICS

Contents Abstract Nigeria has the second highest HIV/AIDS burden in the world with an estimated 3,391,546 people living with HIV and AIDS; an estimated 239,155 people...

EFFECTS OF ENVIRONMENTAL EXPOSURE ON THE PHARMACOKINETICS OF CIPROFLOXACIN TABLET IN HEALTHY HUMAN VOLUNTEERS

Contents ABSTRACT Ciprofloxacin is a fluoroquinolone antibiotic that is commonly prescribed empirically in Nigeria due to its broad spectrum of activity. However, the drug product is...

EFFECTS OF VITAMIN B COMPLEX THERAPY ON TEMPORAL VARIATION IN GENTAMICIN NEPHROTOXICITY IN WISTAR RATS

Contents ABSTRACT The efficacy and toxicity of several drugs is circadian-rhythm dependent, and this can be exploited as a guide to ameliorate such drug toxicity. Gentamicin...

EVALUATION OF NOOTROPIC ACTIVITY OF METHANOL STEM EXTRACT OF PARQUETINA NIGRESCENS AFZEL IN MICE

Contents ABSTRACT Parquetina nigrescens is a plant with numerous ethnomedicinal uses in African traditional medicine practice. In the South Western part of Nigeria, the stems and...

EVALUATION OF THE GASTROPROTECTIVE AND SUB-CHRONIC TOXICITY OF METHANOL STEM BARK EXTRACT OF XIMENIA AMERICANA LINN (OLACACEAE) IN MALE WISTAR RATS

Contents Abstract Ximenia americana is a plant used traditionally in northern parts of Nigeria for treatment of leprotic ulcers and mouth ulcers in addition to other...

FORMULATION STUDIES OF TABLETS CONTAINING ADANSONIA DIGITATA L. MUCILAGE AS MATRIX FORMER

ABSTRACT The aim of this study was to investigate the ability of Adansonia digitata mucilage (ADM), a hydrophilic plant polymeric material to prolong the release...

IMPACT OF PHARMACIST’S INTERVENTION ON PATIENTS’ KNOWLEDGE AND ATTITUDE TOWARDS THEIR DIABETES MANAGEMENT IN A TERTIARY HOSPITAL IN NIGERIA

Contents ABSTRACT Diabetes mellitus (DM) is the most common endocrine disorder. It is a chronic metabolic condition characterized by hyperglycaemia due to impaired insulin secretion with...

ISOLATION AND MOLECULAR CHARACTERIZATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS FROM POULTRY AND POULTRY FARM WORKERS

Contents ABSTRACT The increasing rate of drug resistance associated with methicillin resistant Staphylococcus aureus is not only a problem in the clinical sector but also in...

MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN UNIVERSITY OF JOS COMMUNITY

ABSTRACT Staphylococcus aureus is a virulent pathogen that is currently not only the most common cause of infections in hospitalized patients worldwide but increasingly also...

PHARMACOGNOSTIC AND ANTIULCER STUDIES ON THE LEAF OF LEUCAS MARTINICENSIS (JACQ) R.Br. (LAMIACEAE)

ABSTRACT Leucas martinicensis is an annual herb which is used for repellant of mosquito. It has minty odor. It is an erect plant which is...

PHARMACOLOGICAL INTERACTION BETWEEN ETHANOL EXTRACT OF MORINGA OLEIFERA LEAVES AND METFORMIN IN ALLOXAN-INDUCED HYPERGLYCAEMIC WISTAR RATS

Abstract Herbs with anti-diabetic activity could initiate interactions if used concurrently with orthodox drugs. Moringa oleifera is one of such herbs usually taken as an...

PHYSICOCHEMICAL AND RHEOLOGICAL MODELLING OF SYNERGISTIC INTERACTION OF SOME PLANT GUM EXUDATES

ABSTRACT The visco-elastic properties of Khayasenegalensis (KS gum), Anacardium occidentale (AO gum) and Acacia Senegal (AS gum) blends in dilute solution were investigated. The gums...

PHYTOCHEMICAL AND ANTICONVULSANT STUDIES OF METHANOL LEAF EXTRACT OF HYMENOCARDIA ACIDA, TUL (EUPHORBIACEAE)

ABSTRACT The research was on the phytochemical and anticonvulsant studies of methanol leafextract of Hymenocardia acida, Tul, (Euphorbiaceae) used inNorthern Nigeria for the treatment of...

PHYTOCHEMICAL AND ANTICONVULSANT STUDIES ON METHANOL EXTRACT OF THE ROOT BARK OF UVARIA CHAMA EP. BEAUV. (ANNONACEAE)

ABSTRACT Uvariachamae P. Beauv. (Annonaceae) is widely distributed inAfrica, the plant species are used in traditional medicine as an anti-inflamatory, antimalarial, and analgesic. It is...

PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF Spermacoce verticillata (Rubiaceae)

ABSTRACT The plant Spermacoce verticillata is used in ethnomedicine for the treatment of itches, diarrhoea, sores and other ailments. The hexane soluble fraction of acetone...

PHYTOCHEMICAL AND ANTIMICROBIAL ACTIVITIES ON THE STEM-BARK OF COMMIPHORA MOLLIS (Oliv.) Engl. (BURSERACEAE)

ABSTRACT Commiphora mollis is traditionally used in the treatment of fever (malaria and typhoid) wound healing, cancer, ulcer and rheumatic condition. The plant grows in...

PHYTOCHEMICAL AND INHIBITION STUDIES OF GARCINIA KOLA HECKEL (GUTTIFERAE) SEED EXTRACTS ON SOME KEY ENZYMES INVOLVED WITH DIABETES

ABSTRACT Garcinia kola is an Angiosperm belonging to the family Guttiferae. It is known in commerce as bitter kola. The plant seeds have been used...

PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF THE BARK OF MITRAGYNA INERMIS (WILLD) O. KUNTZE (RUBIACEAE)

ABSTRACT The bark of Mitragyna inermis (Wild) 0. Kuntze was screened phytochemically and the results of the preliminary studies on the light petroleum ether and...

SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM

ABSTRACT The aim of this study was to enhance the solubility and hence dissolution rate of two poorly soluble drugs: ibuprofen and piroxicam using Eudragit...

SPECTROPHOTOMETRIC DETERMINATION AND STABILITY STUDIES OF ARTEMETHER IN ARTEMETHER-LUMEFANTRINE SUSPENSIONS MARKETED IN ZARIA, NIGERIA

ABSTRACT The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for analytical methods for the quality control of...

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